Open TCI

Coetzee 1995 Validation Study

  • Published: [1]
  • Population: 30 adult patients, arterial samples.
  • Description: These are the data gathered by Johan Coetzee to prospectively compare the performance of the “Dyck”, “Marsh”, and “Tackley” parameter sets. It provided the experimental validation that the “Marsh” PK data set was the proper set for the Diprifusor.
  • Description: CSV files with the concentration and covariate data, NONMEM ready.
  • Data: coetzee_validation.zip (File missing – to be located asap!)

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  1. Coetzee J, Glen J, Wium C, Boshoff L: Pharmacokinetic model selection for target controlled infusions of propofol. Assessment of three parameter sets. Anesthesiology 1995; 82:1328–45 PMID: 7793646

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The Open TCI Initiative was developed initially by Dr Charles Minto (Sydney, Australia) & Professor Thomas Schnider (St Gallen, Switzerland) based on many discussions over the past years. This opentci.org website was born on 6 January 2008.

The three main goals of the Open TCI Initiative were further developed in discussion with our mentor, Professor Steven L. Shafer, on 17 January 2008 and others at the first meeting in Cape Town on 3 March 2008.

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