Steven L. Shafer, M.D.
Professor of Anesthesiology
Columbia University
New York, NY 10032
Phone: 212 305 8206

E-mail: sshafer@columbia.edu

My professional interests are the clinical pharmacology of intravenous anesthetic drugs. This has led me to clinical studies of many of the intravenous opioids and hypnotics used in anesthetic practice. However, my passion is not the drugs themselves, but rather the mathematical models that characterize drug behavior. These include conventional pharmacokinetic and pharmacodynamic models, inverse models (used to drive target controlled infusion systems), Bayesian models (used to handle model uncertainty), pharmacokinetic and pharmacodynamic models of drug interaction, and models that relate drug behavior to “in silico” pharmacogenetics.

Within the past 5 years I have consulted for for Alaris, Alexza, Alza, Amphistar, Cognetix, Delex, Durect, Endo Pharmacueticals, Guilford, Jazz, PainCeptor, Renovis, Theravance, and Xenoport. These relationship were terminated either before or at the time of my accepting the position of Editor-in-Chief of Anesthesia & Analgesia. My two ongoing consulting relationships are with Ethicon-Endo Surgical, where I chair the “Anesthesia Advisory Panel” for their Sedation Delivery System, and PharmacoFore, a biotechnology company, which I cofounded and hold approximately a 10% equity interest.