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Table of Contents

Propofol

How do I upload my data?

We can do it for you

  • You can send your data files to Steve Shafer: sshafer@columbia.edu, and Steve will format the data for you and post it to the site. Or, you can follow the steps below.

You can do it yourself

  • Click on “login” link (top right)
  • Click the “edit this page” tab above.
  • Copy, paste and edit someone else's entry!
  • Please provide a link to your publication and a brief description of your data.
  • To upload your data, click on the picture icon in the tool bar above (the icon fourth from the right, adjacent to the smiley face). Suggested format—an Excel file, or a zip file.
  • (Alternatively, you can upload your data first). Click the “Upload file” link (see toolbox menu left).1)
  • Assuming that you uploaded a file into the :data:propofol namespace called dummydata.xls, use the following syntax to refer to the file: {{:data:propofol:dummydata.xls}}. The link will then show up on the page like this: dummydata.xls

Data Sets

Bailey et al.

  • Publication: Anesthesiology. 1996;84:1288-97.
  • Learning set population: 30 adult patients, cardiopulmonary bypass, arterial samples
  • Test set population: 11 adult patients, cardiopulmonary bypass, no covariates
  • Description: CSV files with the concentration and covariate data, NONMEM ready. Learning and test sets.
  • Data: learning set
  • Data: test set

Billard 1998 Propofol

  • Publication: Unpublished
  • Population: 61 adult patients, venous samples
  • Description: These are the data gathered by Valerie Billard.
  • Description: CSV files with the concentration and covariate data, NONMEM ready + Control file.
  • Data: billard.zip

Coetzee Propofol Linearity

  • Publication: Unpublished
  • Population: 69 adult patients, arterial samples
  • Description: These are the data gathered by Johan Coetzee to investigate whether propofol concentration or the presence of sufentanil influence propofol pharmacokinetics.
  • Description: CSV files with the concentration and covariate data, NONMEM ready + Control file.
  • Data: Coetzee linearity.zip

Coetzee Validation Study

  • Publication: Anesthesiology 1995;82:1328-45.
  • Population: 30 adult patients, arterial samples
  • Description: These are the data gathered by Johan Coetzee to prospectively compare the performance of the “Dyck”, “Marsh”, and “Tackley” parameter sets. It provided the experimental validation that the “Marsh” PK data set was the proper set for the Diprifusor.
  • Description: CSV files with the concentration and covariate data, NONMEM ready.
  • Data: Coetzee_linearity.zip

Doufas Induction Speed Study

Doufas DeRamp Study

  • Publication: Unpublished (manuscript using these data is in review at A&A).
  • Population: 10 adult volunteers, 58 arterial samples.
  • Description: CSV files with the concentration and covariate data. NONMEM ready.
  • Data: Doufas DeRamp.zip

Doufas Fixed Reduction Study

  • Publication: Unpublished (manuscript using these data is in review at A&A - same paper as has the DeRamp data above).
  • Population: 10 adult volunteers, 120 arterial samples.
  • Description: CSV files with the concentration and covariate data. NONMEM ready.
  • Data: Doufas Fixed Reduction.zip

Doufas Redhead Study

  • Publication: Unpublished (manuscript in preparation comparing PK and PD of propofol in redheads with propofol in individuals with dark hair).
  • Population: 29 adult volunteers, 374 arterial samples.
  • Description: CSV files with the concentration and covariate data. NONMEM ready.
  • Data: Doufas Redhead.zip

Dyck et al.

  • Publication: Dyck JB, Shafer SL: Effects of age on propofol pharmacokinetics. Seminars in Anesthesia 11:2-4, 1992 (not peer reviewed)
  • Population: 61 adult volunteers, arterial samples
  • Description: These are the data gathered by John Varvel, Orlando Hung, and Steve Shafer, analyzed by Barry Dyck, with a preliminary publication in Seminars in Anesthesia. They are the “Dyck” pharmacokinetics tested by Johan Coetzee in his validation trial, Anesthesiology 1995;82:1328-45. Barry was working on the final manuscript at the time of his death.
  • Description: CSV files with the concentration and covariate data, NONMEM ready + Control file.
  • Data: dyck.zip

Gepts et al.

  • Publication: Anesthesia & Analgesia 1987;66:1256-63.
  • Population: 16 adult patients, arterial samples
  • Description: These are the data that became the “Marsh” pharmacokinetic parameters used in the Diprifusor. Thanks to Margaret Minkwitz, Director, Statistical Sciences (Neuroscience) at AstraZeneca for tracking down the original data files, including all of the covariates! A special “Thank you” also goes to Elisabeth Gepts and Iain Glen for their help in tracking down these data, which were gathered 25 years ago.
  • Description: CSV files with the concentration and covariate data, NONMEM ready.
  • Data: Gepts 1987.zip

Kataria et al.

  • Publication: Anesthesiology 1994;80:104-22.
  • Population: 53 pediatric patients, 3-11 years old, venous samples
  • Description: CSV files with the concentration and covariate data, NONMEM ready + Control file.
  • Data: kataria.zip

Schnider et al.

Servin et al, propofol in obese patients

Servin et al, propofol in alcoholic patients

Struys et al, Propofol bolus study

NONMEM Control files

Cortínez et al.

Avinash Puri et al.

1) The upload file link takes you to the directory matching your current namespace. If you are reading the minutes, and then click upload, it will automatically take you to the minutes directory. Registered users only have permission to upload to the :data namespace.

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